*In PACE: 82% and 59% of CP-CML responders are estimated to maintain MCyR and MMR at 5 years, respectively (Kaplan-Meier estimates).2 For CP-CML patients, the probability
of survival at 2, 3, 4, and 5 years is estimated as 86.0%, 81.2%, 76.9%, and 73.3%, respectively.1 In OPTIC: 48% of patients who received the 45 mg starting dose achieved MCyR
at 12 months;1 the response-based dosing regimen resulted in a clinically-manageable safety profile3
References: 1. Incyte. ICLUSIG summary of product characteristics. March 2022. 2. Cortes JE, et al. Blood. 2018;132(4):393–404. 3. Cortes J, et al. Blood. 2021;138(21):2042–50
2G, second generation;
CML, chronic myeloid leukaemia;
CP, chronic phase;
MCyR, major cytogenetic response;
MMR, major molecular response;
Ponatinib Treatment in CP-CML; PACE, Ponatinib Ph+ ALL and CML Evaluation; Ph+ ALL, Philadelphia chromosome-positive acute lymphoblastic leukaemia; TKI, tyrosine kinase inhibitor
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